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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHUK All Species: 35.76
Human Site: S454 Identified Species: 78.67
UniProt: O15111 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15111 NP_001269.3 745 84654 S454 G Q R A A M L S L L R Y N A N
Chimpanzee Pan troglodytes XP_001167720 745 84642 S454 G Q R A A M L S L L R Y N A N
Rhesus Macaque Macaca mulatta XP_001107171 745 84635 S454 G Q R A A M L S L L R Y N A N
Dog Lupus familis XP_534990 745 84877 S454 G Q R A A M L S L L R Y N A N
Cat Felis silvestris
Mouse Mus musculus Q60680 745 84710 S454 G Q R A A M L S L L R Y N A N
Rat Rattus norvegicus Q9QY78 757 86848 N457 G Q R A A M M N L L R N N S C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513035 723 82400 S432 G Q R A A M L S L L R Y N A N
Chicken Gallus gallus Q5ZJB4 759 86125 S468 G Q R A A M L S L L R Y N A N
Frog Xenopus laevis Q6GM53 743 85134 S452 G Q R A A M L S L L R F N T N
Zebra Danio Brachydanio rerio Q4G3H4 758 87129 S455 G Q R A A M L S L L R F N T N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VEZ5 751 86354 R475 N K F K T K E R W L Q K R V V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.5 97.7 N.A. 95.5 49.1 N.A. 80.1 80.1 72.6 62.9 N.A. 24.3 N.A. N.A. N.A.
Protein Similarity: 100 99.8 99.8 98.7 N.A. 97.4 66.7 N.A. 86.9 88.9 85.6 77.8 N.A. 45 N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 66.6 N.A. 100 100 86.6 86.6 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 86.6 N.A. 100 100 93.3 93.3 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 91 91 0 0 0 0 0 0 0 0 64 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 0 19 0 0 0 % F
% Gly: 91 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 10 0 10 0 10 0 0 0 0 0 10 0 0 0 % K
% Leu: 0 0 0 0 0 0 82 0 91 100 0 0 0 0 0 % L
% Met: 0 0 0 0 0 91 10 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 0 0 0 0 0 10 0 0 0 10 91 0 82 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 91 0 0 0 0 0 0 0 0 10 0 0 0 0 % Q
% Arg: 0 0 91 0 0 0 0 10 0 0 91 0 10 0 0 % R
% Ser: 0 0 0 0 0 0 0 82 0 0 0 0 0 10 0 % S
% Thr: 0 0 0 0 10 0 0 0 0 0 0 0 0 19 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 64 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _